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3 options ranked by Trust Score · April 2026
About Mastra
TypeScript-first AI agent framework with built-in workflows, memory, and RAG — designed for production Node.js and Next.js apps.
OpenAI's official Python SDK for building agents with tool calling, handoffs, and tracing — the successor to the Assistants API.
Type-safe Python agent framework from the Pydantic team — build agents with structured inputs/outputs validated by Pydantic models.
Microsoft's framework for building multi-agent AI systems where agents collaborate, debate, and solve complex tasks conversationally.
Trust Scores are calculated weekly from real-world signals — npm/PyPI downloads, GitHub commits, stars, and Stack Overflow activity. Higher is more actively maintained and widely adopted.
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